SportsLine's model simulated Seattle Seahawks vs. San Francisco 49ers 10,000 times and made its Week 11 NFL picks, ...

Preview the Week 11 matchup between the San Francisco 49ers and Seattle Seahawks with predictions, odds, over/under, spread, ...

The San Francisco 49ers need a win in Week 11 over the Seattle Seahawks. Their injury situation may make it a significant ...

The quarterback is winless in five starts against the 49ers and Seahawks have lost six consecutive games to the 49ers in the ...

Don’t expect the San Francisco 49ers to take their foot off the gas in their usage of running back Christian McCaffrey.

The Seahawks have ruled out three players for Sunday's game against the 49ers, including a key part of the offensive line.

Matt Lively reports on three things that will help the San Francisco 49ers seal a sweep over the Seattle Seahawks on Sunday.

Metcalf hasn’t played since he sprained his knee Oct. 20. Lucas will be making his season debut. Connor Williams is out at ...

San Francisco head coach Kyle Shanahan discussed Friday the 49ers' offensive line ahead of a matchup with the Seattle ...

Christian McCaffrey had 107 yards from scrimmage in his season debut. The 49ers are a different team when McCaffrey is on the ...

The Seattle Seahawks are coming off their bye week, so they'll have fresh legs when they get whooped once again by Kyle ...

The San Francisco 49ers squeaked out a win against the Tampa Bay Buccaneers and will now host the Seattle Seahawks in an NFC ...